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Observe Intently (three)pentobarbital will lessen the extent or influence of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. Sturdy or average CYP3A4 inducers could increase price of diazepam elimination; consequently, efficacy of diazepam might be lowered.pentobarbital will decrease the extent or im